FR139317
FR139317 (PD 147953) is a selective ETA receptor antagonist. FR139317 inhibits cerebral activation by intraventricular endothelin-1 in conscious rats. FR139317 also ameliorates cerebral vasospasm in dogs[1][2].
Product Specifications
CAS Number
142375-60-8
Product Name Alternative
PD 147953
UNSPSC
12352005
Target
Endothelin Receptor
Type
Reference compound
Related Pathways
GPCR/G Protein
Field of Research
Cardiovascular Disease
Assay Protocol
https://www.medchemexpress.com/fr139317.html
Smiles
O=C(O)[C@@H](CC1=NC=CC=C1)NC([C@@H](CC2=CN(C)C3=CC=CC=C23)NC([C@H](CC(C)C)NC(N4CCCCCC4)=O)=O)=O
Molecular Formula
C33H44N6O5
Molecular Weight
604.74
References & Citations
[1]Gross PM, et al. FR139317, a specific ETA-receptor antagonist, inhibits cerebral activation by intraventricular endothelin-1 in conscious rats. Neuropharmacology. 1994 Oct;33 (10) :1155-66. |[2]Nirei H, et al. An endothelin ETA receptor antagonist, FR139317, ameliorates cerebral vasospasm in dogs. Life Sci. 1993;52 (23) :1869-74.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
Phase 2
Isoform
ETA
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