Denbufylline
Denbufylline (BRL 30892) is an inhibitor of phosphodiesterase-4 (PDE4) . Denbufylline is able to block the degradation of intracellular cAMP (cyclic adenosine phosphate) thereby increasing the level of intracellular cAMP, which helps regulate a variety of cellular functions. Denbufylline can be used in the study of chronic obstructive pulmonary disease (COPD), asthma and other inflammatory diseases[1].
Product Specifications
CAS Number
57076-71-8
Product Name Alternative
BRL 30892
UNSPSC
12352005
Target
Phosphodiesterase (PDE)
Type
Reference compound
Related Pathways
Metabolic Enzyme/Protease
Applications
COVID-19-immunoregulation
Field of Research
Inflammation/Immunology; Others
Assay Protocol
https://www.medchemexpress.com/denbufylline.html
Purity
99.92
Solubility
DMSO : 33 mg/mL (ultrasonic; warming)
Smiles
O=C(N1CCCC)N(CCCC)C2=C(N(CC(C)=O)C=N2)C1=O
Molecular Formula
C16H24N4O3
Molecular Weight
320.39
References & Citations
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Reference compound1
Clinical Information
Phase 3
Frequently Asked Questions
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