CRT0273750

CRT0273750 is an autotaxin (ATX) inhibitor and modulates LPA levels in plasm (IC50 = 0.014 μM) . CRT0273750 can be used in ATX/LPA-dependent models of cancer[1].

Product Specifications

CAS Number

[1979939-16-6]

Product Name Alternative

IOA-289

UNSPSC

12352005

Target

LPL Receptor

Type

Reference compound

Related Pathways

GPCR/G Protein

Applications

Cancer-programmed cell death

Field of Research

Cancer

Assay Protocol

https://www.medchemexpress.com/crt0273750.html

Purity

98.81

Solubility

DMSO : 175 mg/mL (ultrasonic; warming; heat to 60°C)

Smiles

FC(F)(OC1=CC=C(C=C1)CN2C(CCC(N[C@H](C3=CC=C(Cl)C=C3)C)=O)=NC4=CC=CN=C42)F

Molecular Formula

C25H22ClF3N4O2

Molecular Weight

502.92

References & Citations

[1]Shah P, et al. Discovery of potent inhibitors of the lysophospholipase autotaxin. Bioorg Med Chem Lett. 2016;26 (22) :5403-5410.

Shipping Conditions

Room Temperature

Storage Conditions

-20°C, 3 years; 4°C, 2 years (Powder)

Scientific Category

Reference compound1

Clinical Information

Phase 2

Available Sizes

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