CRT0273750
CRT0273750 is an autotaxin (ATX) inhibitor and modulates LPA levels in plasm (IC50 = 0.014 μM) . CRT0273750 can be used in ATX/LPA-dependent models of cancer[1].
Product Specifications
CAS Number
[1979939-16-6]
Product Name Alternative
IOA-289
UNSPSC
12352005
Target
LPL Receptor
Type
Reference compound
Related Pathways
GPCR/G Protein
Applications
Cancer-programmed cell death
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/crt0273750.html
Purity
98.81
Solubility
DMSO : 175 mg/mL (ultrasonic; warming; heat to 60°C)
Smiles
FC(F)(OC1=CC=C(C=C1)CN2C(CCC(N[C@H](C3=CC=C(Cl)C=C3)C)=O)=NC4=CC=CN=C42)F
Molecular Formula
C25H22ClF3N4O2
Molecular Weight
502.92
References & Citations
[1]Shah P, et al. Discovery of potent inhibitors of the lysophospholipase autotaxin. Bioorg Med Chem Lett. 2016;26 (22) :5403-5410.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Reference compound1
Clinical Information
Phase 2
Available Sizes
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Oct4, Control Peptide (KLH) (POU Domain, Class 5, Transcription Factor 1 Oct3/4, POU5F1, HGNC:9221, MGC22487, Octamer-binding Transcription Factor 3, Oct3, OTF3, OTF4, POU-type Homeodomain-containing DNA-binding Protein)
