Suprafenacine
Suprafenacine is a cell permeable, tubulin-destabilizing molecule which bind microtubules at the colchicine-binding site and inhibit polymerization. Suprafenacine can induce G2/M cell cycle arrest and apoptosis, and can be used for cancer research[1].
Product Specifications
CAS Number
[1477482-50-0]
Product Name Alternative
SRF
UNSPSC
12352005
Target
Microtubule/Tubulin
Type
Reference compound
Related Pathways
Cell Cycle/DNA Damage; Cytoskeleton
Applications
Cancer-programmed cell death
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/suprafenacine.html
Purity
98.0
Solubility
DMSO : 10 mg/mL (ultrasonic; warming)
Smiles
O=C(N/N=C/C1=CC=C(C=C1)C)C2=NNC3=C2CCCC3
Molecular Formula
C16H18N4O
Molecular Weight
282.34
References & Citations
[1]Choi BH, et al. Suprafenacine, an indazole-hydrazide agent, targets cancer cells through microtubule destabilization. PLoS One. 2014 Oct 29;9 (10) :e110955.
Shipping Conditions
Blue Ice
Storage Conditions
-20°C, 3 years (Powder)
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Available Sizes
Curated Selection
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