Suprafenacine

Suprafenacine is a cell permeable, tubulin-destabilizing molecule which bind microtubules at the colchicine-binding site and inhibit polymerization. Suprafenacine can induce G2/M cell cycle arrest and apoptosis, and can be used for cancer research[1].

Product Specifications

CAS Number

[1477482-50-0]

Product Name Alternative

SRF

UNSPSC

12352005

Target

Microtubule/Tubulin

Type

Reference compound

Related Pathways

Cell Cycle/DNA Damage; Cytoskeleton

Applications

Cancer-programmed cell death

Field of Research

Cancer

Assay Protocol

https://www.medchemexpress.com/suprafenacine.html

Purity

98.0

Solubility

DMSO : 10 mg/mL (ultrasonic; warming)

Smiles

O=C(N/N=C/C1=CC=C(C=C1)C)C2=NNC3=C2CCCC3

Molecular Formula

C16H18N4O

Molecular Weight

282.34

References & Citations

[1]Choi BH, et al. Suprafenacine, an indazole-hydrazide agent, targets cancer cells through microtubule destabilization. PLoS One. 2014 Oct 29;9 (10) :e110955.