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Cynomolgus Cadherin-17 / CDH17 Protein, Fc Tag (MALS verified)

Cadherin-17, also known as liver-intestine (LI) Cadherin, belongs to the cadherin family of calcium-dependent cell adhesion molecules. In vivo studies showed CDH17 knockout resulted in apoptotic PC tumor death through activating caspase-3 activity. Taken together, CDH17 functions as an oncogenic molecule critical to PC growth by regulating tumor apoptosis signaling pathways and CDH17 could be targeted to develop an anti-PC therapeutic approach.

Product Specifications

Background

Cadherin-17, also known as liver-intestine (LI) Cadherin, belongs to the cadherin family of calcium-dependent cell adhesion molecules. In vivo studies showed CDH17 knockout resulted in apoptotic PC tumor death through activating caspase-3 activity. Taken together, CDH17 functions as an oncogenic molecule critical to PC growth by regulating tumor apoptosis signaling pathways and CDH17 could be targeted to develop an anti-PC therapeutic approach.

Specifications

This protein carries a human IgG1 Fc tag at the C-terminus. The protein has a calculated MW of 111.1 kDa. The protein migrates as 130-150 kDa when calibrated against Star Ribbon Pre-stained Protein Marker under reducing (R) condition (SDS-PAGE) due to glycosylation.

Accession Number

A0A2K5X8I8-1

Expression Region

Lys 30 - Thr 792

Host

HEK293

Target

Cadherin-17

Conjugation

Unconjugated

Tag

C-Fc

Source

Cynomolgus

Stability

-20°C to -70°C for 12 months in lyophilized state; -70°C for 3 months under sterile conditions after reconstitution. For long term storage, the product should be stored at lyophilized state at -20°C or lower.

Endotoxin

1.0 EU per μg

Purity

90%

Bioactivity

Immobilized Cynomolgus Cadherin-17 Protein, Fc Tag (Cat. No. CA7-C5253) at 1 μg/mL (100 μL/well) can bind Anti-CDH17 antibody with a linear range of 2-63 ng/mL (QC tested).

Format

Powder

Buffer

PBS, pH7.4

Additives

Trehalose

Molecular Weight

111.1 kDa

Additionnal Information

Please see 'Shipping-and-Payments' sheet. Website: https://www.acrobiosystems.com/support/shipping-and-payments

Shipping Conditions

RT

Storage Conditions

-20°C

Package Size

1mg*1

Product Datasheet

https://console.acrobiosystems.com/public/product/pdf/ds/CA7-C5253.pdf

Host or Source

HEK293

Species

Cynomolgus

Protein ID

A0A2K5X8I8-1

Preservative

Trehalose

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