MALT1-IN-13
Product Specifications
UNSPSC Description
MALT1-IN-13 (compound 10m) is inhibitor for mucosa-associated lymphoid tissue lymphoma translocation protein 1 (MALT1), which to binds MALT1 protease covalently and irreversibly, inhibits MALT1 with the IC50 of 1.7 μM. MALT1-IN-13 inhibits proliferation against ABC-DLBCL and induces apoptosis in ABC-DLBCL HBL1. MALT1-IN-13 regulates mTOR and PI3K-Akt pathways[1].
Target Antigen
Apoptosis; MALT1
Type
Reference compound
Related Pathways
Apoptosis;Metabolic Enzyme/Protease;NF-κB
Applications
COVID-19-immunoregulation
Field of Research
Cancer; Inflammation/Immunology
Assay Protocol
https://www.medchemexpress.com/malt1-in-13.html
Solubility
10 mM in DMSO
Smiles
O=C1C(S2)=C(N=C(N1C3=CC(OC)=CC=C3OC)CBr)N(C4=CC=CC(Cl)=C4)C2=S
Molecular Weight
524.84
References & Citations
[1]Liang X, et al., Development of Potent MALT1 Inhibitors Featuring a Novel "2-Thioxo-2,3-dihydrothiazolo[4,5-d]pyrimidin-7(6H)-one" Scaffold for the Treatment of B Cell Lymphoma. J Med Chem. 2024 Feb 22;67(4):2884-2906.|[2]Liang X, et al., Development of Potent MALT1 Inhibitors Featuring a Novel "2-Thioxo-2,3-dihydrothiazolo[4,5-d]pyrimidin-7(6H)-one" Scaffold for the Treatment of B Cell Lymphoma. J Med Chem. 2024 Feb 22;67(4):2884-2906.
Shipping Conditions
Room temperature
Product Datasheet
http://file.medchemexpress.com/batch_PDF/HY-162268/MALT1-IN-13-DataSheet-MedChemExpress.pdf
Product MSDS
http://file.medchemexpress.com/batch_PDF/HY-162268/
Clinical Information
No Development Reported
Curated Selection
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