ROCK-IN-1
ROCK-IN-1 is a potent inhibitor of ROCK, with an IC50 of 1.2 nM for ROCK2.
Product Specifications
CAS Number
[934387-35-6]
UNSPSC
12352005
Target
ROCK
Type
Reference compound
Related Pathways
Cell Cycle/DNA Damage; Cytoskeleton; Stem Cell/Wnt; TGF-beta/Smad
Applications
COVID-19-anti-virus
Field of Research
Inflammation/Immunology; Cardiovascular Disease
Assay Protocol
https://www.medchemexpress.com/[1,1_acute_-Biphenyl]-3-carboxamide,_6-_1-aminoethyl_-4_acute_-fluoro-N-4-pyridinyl-.html
Purity
98.17
Solubility
DMSO : 100 mg/mL (ultrasonic)
Smiles
O=C(C1=CC(C2=CC=C(F)C=C2)=C(C(N)C)C=C1)NC3=CC=NC=C3
Molecular Formula
C20H18FN3O
Molecular Weight
335.37
References & Citations
[1]Boland S, et al. 3-[2- (Aminomethyl) -5-[ (pyridin-4-yl) carbamoyl]phenyl] benzoates as soft ROCK inhibitors. Bioorg Med Chem Lett. 2013 Dec 1;23 (23) :6442-6.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
ROCK2
Available Sizes
Curated Selection
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