CC-115 (hydrochloride)
CC-115 hydrochloride is a potent and dual DNA-PK and mTOR kinase inhibitor with IC50s of 13 nM and 21 nM, respectively. CC-115 blocks both mTORC1 and mTORC2 signaling.
Product Specifications
CAS Number
[1300118-55-1]
UNSPSC
12352005
Target
DNA-PK; mTOR
Type
Reference compound
Related Pathways
Cell Cycle/DNA Damage; PI3K/Akt/mTOR
Applications
Cancer-Kinase/protease
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/CC-115-hydrochloride.html
Purity
98.03
Solubility
DMSO : ≥ 30 mg/mL|H2O : 50 mg/mL (ultrasonic)
Smiles
[H]Cl.O=C1CN=C2C(N1CC)=NC(C3=C(C)N=C(C4=NN=CN4)C=C3)=CN2
Molecular Formula
C16H17ClN8O
Molecular Weight
372.81
References & Citations
Shipping Conditions
Room Temperature
Storage Conditions
4°C (Powder, sealed storage, away from moisture)
Scientific Category
Reference compound1
Clinical Information
Phase 1
Isoform
MTOR; mTORC1; mTORC2
Citation 01
Front Pharmacol. 2020 Nov 11;11:580407.|Front Pharmacol. 2020 Nov 11;11:580407.|Sci Data. 2024 Sep 19;11 (1) :1024.
Available Sizes
Explore Other Products
Discover premium biology products from our extensive collection of 20M+ items
PHF13, CT (PHF13, PHD finger protein 13, Survival time-associated PHD finger protein in ovarian cancer 1) (MaxLight 490)
PHF13, CT (PHF13, PHD finger protein 13, Survival time-associated PHD finger protein in ovarian cancer 1) (MaxLight 490)
