8-CPT-Cyclic AMP (sodium)
8-CPT-Cyclic AMP (8-CPT-cAMP) sodium is a selective activator of cyclic AMP-dependent protein kinase (PKA) . 8-CPT-Cyclic AMP sodium is also a potent inhibitor of the cyclic GMP-specific phosphodiesterase (PDE VA) with an IC50 of 0.9 μM. 8-CPT-Cyclic AMP sodium also inhibits PDE III and PDE IV with IC50Epac and is a potent Epac activator[1][2].
Product Specifications
CAS Number
93882-12-3
Product Name Alternative
8-CPT-cAMP (sodium) ; 8- (p-Chlorophenylthio) -cAMP (sodium)
UNSPSC
12352005
Target
Phosphodiesterase (PDE) ; PKA
Type
Reference compound
Related Pathways
Metabolic Enzyme/Protease; Stem Cell/Wnt; TGF-beta/Smad
Applications
COVID-19-immunoregulation
Field of Research
Inflammation/Immunology
Assay Protocol
https://www.medchemexpress.com/8-cpt-cyclic-amp-sodium.html
Concentration
10mM
Purity
99.91
Solubility
DMSO : 62.5 mg/mL (ultrasonic; warming; heat to 60°C) |H2O : 50 mg/mL (ultrasonic)
Smiles
NC1=NC=NC2=C1N=C(N2[C@@H]3O[C@@]4([H])[C@](OP(OC4)(O[Na])=O)([H])[C@H]3O)SC5=CC=C(Cl)C=C5
Molecular Formula
C16H14ClN5NaO6PS
Molecular Weight
493.79
References & Citations
Shipping Conditions
Blue Ice
Storage Conditions
-20°C (Powder, sealed storage, away from moisture)
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Available Sizes
Frequently Asked Questions
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