8-CPT-Cyclic AMP (sodium)

8-CPT-Cyclic AMP (8-CPT-cAMP) sodium is a selective activator of cyclic AMP-dependent protein kinase (PKA) . 8-CPT-Cyclic AMP sodium is also a potent inhibitor of the cyclic GMP-specific phosphodiesterase (PDE VA) with an IC50 of 0.9 μM. 8-CPT-Cyclic AMP sodium also inhibits PDE III and PDE IV with IC50Epac and is a potent Epac activator[1][2].

Product Specifications

CAS Number

[93882-12-3]

Product Name Alternative

8-CPT-cAMP (sodium) ; 8- (p-Chlorophenylthio) -cAMP (sodium)

UNSPSC

12352005

Target

Phosphodiesterase (PDE) ; PKA

Type

Reference compound

Related Pathways

Metabolic Enzyme/Protease; Stem Cell/Wnt; TGF-beta/Smad

Applications

COVID-19-immunoregulation

Field of Research

Inflammation/Immunology

Assay Protocol

https://www.medchemexpress.com/8-cpt-cyclic-amp-sodium.html

Concentration

10mM

Purity

99.91

Solubility

DMSO : 62.5 mg/mL (ultrasonic; warming; heat to 60°C) |H2O : 50 mg/mL (ultrasonic)

Smiles

NC1=NC=NC2=C1N=C(N2[C@@H]3O[C@@]4([H])[C@](OP(OC4)(O[Na])=O)([H])[C@H]3O)SC5=CC=C(Cl)C=C5

Molecular Formula

C16H14ClN5NaO6PS

Molecular Weight

493.79

References & Citations

[1]Connolly BJ, et al. 8- (4-Chlorophenyl) thio-cyclic AMP is a potent inhibitor of the cyclic GMP-specific phosphodiesterase (PDE VA) . Biochem Pharmacol. 1992;44 (12) :2303-2306. |[2]Krakstad C, et al. cAMP protects neutrophils against TNF-alpha-induced apoptosis by activation of cAMP-dependent protein kinase, independently of exchange protein directly activated by cAMP (Epac) . J Leukoc Biol. 2004;76 (3) :641-647.