Carebastine
Carebastine is the active metabolite of Ebastine. Carebastine is a histamine H1 receptor antagonist. Carebastine inhibits VEGF-induced HUVEC and HPAEC proliferation, migration and angiogenesis in a dose-dependent manner[1]. Carebastine suppresses the expression of macrophage migration inhibitory factor[2].
Product Specifications
CAS Number
90729-42-3
UNSPSC
12352005
Hazard Statement
H301, H413
Target
Histamine Receptor; Macrophage migration inhibitory factor (MIF)
Type
Reference compound
Related Pathways
GPCR/G Protein; Immunology/Inflammation; Neuronal Signaling
Applications
Cancer-programmed cell death
Field of Research
Cancer; Endocrinology
Assay Protocol
https://www.medchemexpress.com/carebastine.html
Purity
99.23
Solubility
DMF : 25 mg/mL (ultrasonic; warming) |DMSO : 2 mg/mL (ultrasonic; warming)
Smiles
O=C(CCCN1CCC(OC(C2=CC=CC=C2)C3=CC=CC=C3)CC1)C4=CC=C(C=C4)C(C)(C(O)=O)C
Molecular Formula
C32H37NO4
Molecular Weight
499.64
Precautions
H301, H413
References & Citations
Shipping Conditions
Blue Ice
Storage Conditions
-20°C, 3 years (Powder)
Scientific Category
Reference compound1
Clinical Information
Phase 3
Isoform
H1 Receptor
Available Sizes
Frequently Asked Questions
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