Carebastine

Carebastine is the active metabolite of Ebastine. Carebastine is a histamine H1 receptor antagonist. Carebastine inhibits VEGF-induced HUVEC and HPAEC proliferation, migration and angiogenesis in a dose-dependent manner[1]. Carebastine suppresses the expression of macrophage migration inhibitory factor[2].

Product Specifications

CAS Number

[90729-42-3]

UNSPSC

12352005

Hazard Statement

H301, H413

Target

Histamine Receptor; Macrophage migration inhibitory factor (MIF)

Type

Reference compound

Related Pathways

GPCR/G Protein; Immunology/Inflammation; Neuronal Signaling

Applications

Cancer-programmed cell death

Field of Research

Cancer; Endocrinology

Assay Protocol

https://www.medchemexpress.com/carebastine.html

Purity

99.23

Solubility

DMF : 25 mg/mL (ultrasonic; warming) |DMSO : 2 mg/mL (ultrasonic; warming)

Smiles

O=C(CCCN1CCC(OC(C2=CC=CC=C2)C3=CC=CC=C3)CC1)C4=CC=C(C=C4)C(C)(C(O)=O)C

Molecular Formula

C32H37NO4

Molecular Weight

499.64

Precautions

H301, H413

References & Citations

[1]De Luisi A, et al. Anti-angiogenic activity of carebastine: a plausible mechanism affecting airway remodelling. Eur Respir J. 2009 Oct;34 (4) :958-66.|[2]Zhao Y, et al. Carebastine, an H1-receptor antagonist, suppresses the expression of macrophage migration inhibitory factor. Clin Exp Dermatol. 2008 Nov;33 (6) :785-7.