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Avibactam (sodium) (Standard)

Avibactam (sodium) (Standard) is the analytical standard of Avibactam (sodium) . This product is intended for research and analytical applications. Avibactam sodium (NXL-104) is a covalent and reversible non-β-lactam β-lactamase inhibitor which inhibits β-lactamase TEM-1 and CTX-M-15 with IC50s of 8 nM and 5 nM, respectively[1].

Product Specifications

CAS Number

1192491-61-4

Product Name Alternative

NXL-104 (Standard)

UNSPSC

12352005

Target

Antibiotic; Bacterial; Beta-lactamase; Reference Standards

Type

Reference Standards

Related Pathways

Anti-infection; Others

Field of Research

Infection

Assay Protocol

https://www.medchemexpress.com/avibactam-sodium-standard.html

Purity

99.86

Smiles

O=S(ON1[C@]2([H])CC[C@@H](C(N)=O)[N@@](C2)C1=O)(O[Na])=O

Molecular Formula

C7H10N3NaO6S

Molecular Weight

287.23

References & Citations

[1]Ehmann DE, et al.
 Avibactam is a covalent, reversible, non-β-lactam β-lactamase inhibitor.
 Proc Natl Acad Sci U S A. 2012 Jul 17;109 (29) :11663-8.|[2]Livermore DM, et al.
 Characterization of β-lactamase and porin mutants of Enterobacteriaceae selected with ceftaroline + avibactam (NXL104) .
 J Antimicrob Chemother. 2012 Jun;67 (6) :1354-8.|[3]Berkhout J, et al. Pharmacokinetics and penetration of GR20263 and avibactam into epithelial lining fluid in thigh- and lung-infected mice. Antimicrob Agents Chemother. 2015 Apr;59 (4) :2299-304.|[4]Zhang W, et al. In vitro and in vivo bactericidal activity of ceftazidime-avibactam against Carbapenemase-producing Klebsiella pneumoniae. Antimicrob Resist Infect Control. 2018 Nov 21;7:142.

Shipping Conditions

Blue Ice

Storage Conditions

-20°C, sealed and dry storage, away from light and moisture, under nitrogen

Scientific Category

Reference Standards

Available Sizes

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