VD4162
VD4162 (Compound 8b) is a macrocyclic inhibitor of serine proteases. VD4162 can significantly improve potency for all four target enzymes TMPRSS2 (IC50 = 3.7 nM), HGFA (IC50 = 3.3 nM), matriptase (IC50 = 2.9 nM), and hepsin (IC50 = 0.54 nM) . VD4162 can be used for the research of cancer[1].
Product Specifications
CAS Number
[2574390-19-3]
UNSPSC
12352005
Target
Ser/Thr Protease
Type
Reference compound
Related Pathways
Metabolic Enzyme/Protease
Applications
Cancer-Kinase/protease
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/vd4162.html
Solubility
10 mM in DMSO
Smiles
O=C1[C@@H](CC2=CNC3=C2C=CC=C3)NC([C@H](CC4=CC=C(OCCCC[C@@H](C(N[C@H](C(C5=NC6=C(C=CC=C6)S5)=O)CCCNC(N)=N)=O)N1)C=C4)NC(C)=O)=O
Molecular Formula
C41H47N9O6S
Molecular Weight
793.93
References & Citations
[1]Damalanka VC, et al. Mechanism-Based Macrocyclic Inhibitors of Serine Proteases. J Med Chem. 2024 Mar 28;67 (6) :4833-4854.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
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