1- (Carboxymethyl) cyclohexanecarboxylic acid

1- (Carboxymethyl) cyclohexanecarboxylic acid (1-Carboxycyclohexaneacetic acid; Gabapentin Impurity E) is a potential impurity in commercial preparations of the antiepileptic agent Gabapentin (HY-A0057) . It is also used as a precursor for the synthesis of a serotonin (5-HT) receptor subtype 5-HT2A antagonist.

Product Specifications

CAS Number

[67950-95-2]

Product Name Alternative

1-Carboxycyclohexaneacetic acid; Gabapentin Impurity E; Gabapentin Related Compound E

UNSPSC

12352211

Hazard Statement

H302-H315-H319-H335

Target

5-HT Receptor

Type

Reference compound

Related Pathways

GPCR/G Protein; Neuronal Signaling

Applications

Neuroscience-Neuromodulation

Field of Research

Neurological Disease

Assay Protocol

https://www.medchemexpress.com/1-carboxymethyl-cyclohexanecarboxylic-acid.html

Smiles

O=C(O)CC1(C(O)=O)CCCCC1

Molecular Formula

C9H14O4

Molecular Weight

186.21

Precautions

P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501

References & Citations

[1]Ragham, et al. Development and validation of a stability-indicating RP-HPL C-CAD method for gabapentin and its related impurities in presence of degradation products. J. Pharm. Biomed. Anal. 125, 122-129 (2016) .