Antibacterial agent 241
Antibacterial agent 241 is a histidine kinase (HK) inhibitor, with IC50 values of 14 μM and 238 μM for CckA and PhoQ, respectively. Antibacterial agent 241 shows moderate antibacterial activity against E. coli DC2, Bacillus cereus, and Bacillus subtilis, with a MIC range of 12-74 μg/mL[1].
Product Specifications
CAS Number
[558638-15-6]
UNSPSC
12352005
Target
Bacterial
Type
Reference compound
Related Pathways
Anti-infection
Field of Research
Infection
Assay Protocol
https://www.medchemexpress.com/antibacterial-agent-241.html
Smiles
COC1=CC=C(C=C1)C2=C(NN=C2C3=C(C=C(C(Cl)=C3)O)O)C
Molecular Formula
C17H15ClN2O3
Molecular Weight
330.77
References & Citations
[1]Fernandez-Ciruelos B, et al. Repurposing Hsp90 inhibitors as antimicrobials targeting two-component systems identifies compounds leading to loss of bacterial membrane integrity. Microbiol Spectr. 2024 Aug 6;12 (8) :e0014624.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Curated Selection
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