L-Penicillamine

L-Penicillamine is a mechanism-based inhibitor of serine palmitoyltransferase by forming a pyridoxal-5 '-phosphate-thiazolidine adduct. L-Penicillamine is a metal chelating agent of intermediate strength[1][2].

Product Specifications

CAS Number

[1113-41-3]

UNSPSC

12352209

Hazard Statement

H315, H319, H372, H413

Target

Biochemical Assay Reagents

Type

Peptides

Related Pathways

Others

Applications

Metabolism-protein/nucleotide metabolism

Field of Research

Metabolic Disease

Assay Protocol

https://www.medchemexpress.com/l-penicillamine.html

Purity

97.0

Solubility

H2O : 33.33 mg/mL (ultrasonic)

Smiles

N[C@H](C(O)=O)C(S)(C)C

Molecular Formula

C5H11NO2S

Molecular Weight

149.22

Precautions

H315, H319, H372, H413

References & Citations

[1]Jonathan Lowther, et al. L-Penicillamine is a mechanism-based inhibitor of serine palmitoyltransferase by forming a pyridoxal-5 '-phosphate-thiazolidine adduct. Med. Chem. Commun., 2012,3, 1003-1008.|[2]Roland Degenkolbe, et al. Chelating agents stabilize the monomeric state of the zinc binding human papillomavirus 16 E6 oncoprotein. Biochemistry. 2003 Apr 8;42 (13) :3868-73.