SCH529074
SCH529074 is a potent and orally active p53 activator. SCH529074 binds specifically and conformation-dependently to p53 DBD (DNA binding domain) with a Ki of 1-2 μM in a saturable manner. SCH529074 restores mutant p53 function and interrupts HDM2-mediated ubiquitination of wild Type p53. SCH529074 can be used for the study of non-small-cell lung carcinoma (NSCLC) [1][2].
Product Specifications
CAS Number
922150-11-6
UNSPSC
12352005
Target
MDM-2/p53
Type
Reference compound
Related Pathways
Apoptosis
Applications
Cancer-programmed cell death
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/sch529074.html
Purity
99.73
Solubility
DMSO : 20 mg/mL (ultrasonic)
Smiles
CN(C)CCCNC1=C2C=CC=CC2=NC(CN3CCN(C(C4=CC=C(Cl)C=C4)C5=CC=C(Cl)C=C5)CC3)=N1
Molecular Formula
C31H36Cl2N6
Molecular Weight
563.56
References & Citations
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Available Sizes
Frequently Asked Questions
Explore Other Products
Browse additional items from our catalog
Uncoated Human HP (Haptoglobin) ELISA Kit
Uncoated Human HP (Haptoglobin) ELISA Kit
![TRPS1 Mouse Monoclonal Antibody [Clone ID: OTI1D9]](https://cdn.genprice.uk/products/937/68dd18bb061270361e908eca/imageurl/cf813143.webp)