Nirvanol-d5
Nirvanol-d5 (Ethylphenylhydantoin-d5) is deuterium labeled Nirvanol. Nirvanol (Ethylphenylhydantoin) is a metabolite of Mephenytoin (HY-B1184) that exerts anticonvulsant effects in the maximal electroshock (M.E.S.) seizure model in mice. Nirvanol shows potential for research in epilepsy-related neurological disorders[2].
Product Specifications
CAS Number
119458-27-4
Product Name Alternative
Ethylphenylhydantoin-d5; Phenylethyihydantoin-d5; Desmethylmephenytoin-d5
UNSPSC
12352005
Target
Drug Metabolite; Isotope-Labeled Compounds
Type
Isotope-Labeled Compounds
Related Pathways
Metabolic Enzyme/Protease; Others
Field of Research
Neurological Disease
Solubility
10 mM in DMSO
Smiles
CCC1(C2=C([2H])C([2H])=C([2H])C([2H])=C2[2H])C(NC(N1)=O)=O
Molecular Formula
C11H7D5N2O2
Molecular Weight
209.26
References & Citations
[1]Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019;53 (2) :211-216.|[2]Kupferberg HJ, et al. The metabolism of 3-methyl-5-ethyl-5-phenylhydantoin (mephenytoin) to 5-ethyl-5-phenylhydantoin (Nirvanol) in mice in relation to anticonvulsant activity. Drug Metab Dispos. 1975 Jan-Feb;3 (1) :26-9. PMID: 234831.
Shipping Conditions
Room temperature
Scientific Category
Isotope-Labeled Compounds
Clinical Information
No Development Reported
Available Sizes
Frequently Asked Questions
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