VU0366369
VU0366369 (ML137) is a selective positive allosteric modulator (PAM) for mAChR M1 with an EC50 of 830 nM. VU0366369 can be used in research about central nervous system diseases[1].
Product Specifications
CAS Number
1222834-53-8
Product Name Alternative
ML137
UNSPSC
12352005
Hazard Statement
H302-H315-H319
Target
Cholinesterase (ChE)
Type
Reference compound
Related Pathways
Neuronal Signaling
Field of Research
Neurological Disease
Assay Protocol
https://www.medchemexpress.com/vu0366369.html
Smiles
O=C1C(N(CC2=C(F)C=C(C3=CN(C)N=C3)C=C2)C4=C1C=CC=C4)=O
Molecular Formula
C19H14FN3O2
Molecular Weight
335.33
Precautions
P264-P270-P280-P302+P352-P330-P362+P364-P501
References & Citations
[1]Bridges TM, et al., Chemical lead optimization of a pan Gq mAChR M1, M3, M5 positive allosteric modulator (PAM) lead. Part II: development of a potent and highly selective M1 PAM. Bioorg Med Chem Lett. 2010 Mar 15;20 (6) :1972-5.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Available Sizes
Frequently Asked Questions
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