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Lapachol (Standard)

Lapachol (Standard) is the analytical standard of Lapachol. This product is intended for research and analytical applications. Lapachol, a natural naphthoquinone, is an orally active, potent DHODH inhibitor. Lapachol has immunosuppressive activity on lymphocytes through its direct ability to block DHODH activity and inhibit pyrimidine synthesis. Lapachol is a vitamin K antagonist with antitumor activity and can inhibit DNA and RNA synthesis in neoplastic cells. Lapachol has anti-Leishmania activity[1][2][3].

Product Specifications

CAS Number

84-79-7

UNSPSC

12352005

Target

Dihydroorotate Dehydrogenase; DNA/RNA Synthesis; Parasite; Reference Standards

Type

Reference Standards

Related Pathways

Anti-infection; Cell Cycle/DNA Damage; Metabolic Enzyme/Protease; Others

Field of Research

Cancer; Infection; Inflammation/Immunology

Assay Protocol

https://www.medchemexpress.com/lapachol-standard.html

Smiles

O=C(C(CC=C(C)C)=C1O)C2=CC=CC=C2C1=O

Molecular Formula

C15H14O3

Molecular Weight

242.27

References & Citations

[1]Raphael S Peres, et al. Lapachol, a compound targeting pyrimidine metabolism, ameliorates experimental autoimmune arthritis. Arthritis Res Ther. 2017 Mar 7;19 (1) :47.|[2]Masayo Maeda, et al. Promotion or suppression of experimental metastasis of B16 melanoma cells after oral administration of lapachol. Toxicol Appl Pharmacol. 2008 Jun 1;229 (2) :232-8.|[3]Iasmin Aparecida Cunha Araújo, et al. Efficacy of lapachol on treatment of cutaneous and visceral leishmaniasis. Exp Parasitol. 2019 Apr:199:67-73.

Shipping Conditions

Room temperature

Scientific Category

Reference Standards

Frequently Asked Questions

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