Human Cadherin-17 / CDH17 Protein, Mouse IgG1 Fc Tag (MALS verified)

Cadherin-17, also known as liver-intestine (LI) Cadherin, belongs to the cadherin family of calcium-dependent cell adhesion molecules. In vivo studies showed CDH17 knockout resulted in apoptotic PC tumor death through activating caspase-3 activity. Taken together, CDH17 functions as an oncogenic molecule critical to PC growth by regulating tumor apoptosis signaling pathways and CDH17 could be targeted to develop an anti-PC therapeutic approach.

Product Specifications

Background

Specifications

This protein carries a mouse IgG1 Fc tag at the C-terminus. The protein has a calculated MW of 111.2 kDa. The protein migrates as 130-135 kDa when calibrated against Star Ribbon Pre-stained Protein Marker under reducing (R) condition (SDS-PAGE) due to glycosylation.

Accession Number

Q12864-1

Expression Region

Gln 23 - Met 787

Host

HEK293

Target

Cadherin-17

Conjugation

Unconjugated

Tag

C-mFc (mIgG1)

Source

Human

Stability

-20°C to -70°C for 12 months in lyophilized state; -70°C for 3 months under sterile conditions after reconstitution. For long term storage, the product should be stored at lyophilized state at -20°C or lower.

Endotoxin

0.1 EU per μg

Purity

90%

Bioactivity

Immobilized Human Cadherin-17 Protein, Mouse IgG1 Fc Tag (Cat. No. CA7-H52A9) at 1 μg/mL (100 μL/well) can bind Human Anti-Cadherin 17 with a linear range of 0.5-31 ng/mL (QC tested).