Cyclo(his-pro)
Product Specifications
UNSPSC Description
Cyclo(his-pro) (Cyclo(histidyl-proline)) is an orally active cyclic dipeptide structurally related to tyreotropin-releasing hormone[1]. Cyclo(his-pro) could inhibit NF-κB nuclear accumulation. Cyclo(his-pro) can cross the brain-blood-barrier and affect diverse inflammatory and stress responses[2].
Target Antigen
Endogenous Metabolite; NF-κB
Type
Natural Products
Related Pathways
Metabolic Enzyme/Protease;NF-κB
Applications
Neuroscience-Neuromodulation
Field of Research
Inflammation/Immunology; Neurological Disease
Assay Protocol
https://www.medchemexpress.com/Cyclo_his-pro_.html
Purity
99.41
Solubility
H2O : ≥ 30 mg/mL
Smiles
O=C(N[C@H]1CC2=CN=CN2)[C@@](CCC3)([H])N3C1=O
Molecular Weight
234.25
References & Citations
[1]Grottelli S, et al. The Role of Cyclo(His-Pro) in Neurodegeneration. Int J Mol Sci. 2016 Aug 12;17(8). pii: E1332.|[2]Minelli A, et al. Cyclo(His-Pro) exerts anti-inflammatory effects by modulating NF-κB and Nrf2 signalling. Int J Biochem Cell Biol. 2012 Mar;44(3):525-35.|[3]Bellezza I, et al. Neuroinflammation and endoplasmic reticulum stress are coregulated by cyclo(His-Pro) to prevent LPS neurotoxicity. Int J Biochem Cell Biol. 2014 Jun;51:159-69.
Shipping Conditions
Blue Ice
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Product Datasheet
http://file.medchemexpress.com/batch_PDF/HY-101402/Cyclo-his-pro-DataSheet-MedChemExpress.pdf
Product MSDS
http://file.medchemexpress.com/batch_PDF/HY-101402/Cyclo-his-pro-SDS-MedChemExpress.pdf
Clinical Information
No Development Reported
CAS Number
53109-32-3
Available Sizes
Curated Selection
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