Terfenadine
Terfenadine ((±) -Terfenadine) is a potent open-channel blocker of hERG with an IC50 of 204 nM[1]. Terfenadine, an H1 histamine receptor antagonist, acts as a potent apoptosis inducer in melanoma cells through modulation of Ca2+ homeostasis. Terfenadine induces ROS-dependent apoptosis, simultaneously activates Caspase-4, -2, -9[2].
Product Specifications
CAS Number
50679-08-8
Product Name Alternative
(±) -Terfenadine; MDL-991
UNSPSC
12352005
Hazard Statement
H413
Target
Apoptosis; Caspase; Histamine Receptor; Na+/Ca2+ Exchanger; Potassium Channel
Type
Reference compound
Related Pathways
Apoptosis; GPCR/G Protein; Immunology/Inflammation; Membrane Transporter/Ion Channel; Neuronal Signaling
Applications
Cancer-programmed cell death
Field of Research
Cancer; Inflammation/Immunology; Endocrinology
Assay Protocol
https://www.medchemexpress.com/Terfenadine.html
Concentration
10mM
Purity
99.98
Solubility
DMSO : ≥ 50 mg/mL|H2O : < 0.1 mg/mL
Smiles
OC(C1=CC=C(C(C)(C)C)C=C1)CCCN2CCC(C(C3=CC=CC=C3)(O)C4=CC=CC=C4)CC2
Molecular Formula
C32H41NO2
Molecular Weight
471.67
Precautions
H413
References & Citations
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Reference compound1
Clinical Information
Launched
Isoform
Caspase 2; Caspase 4; Caspase 9; H1 Receptor
Available Sizes
Frequently Asked Questions
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