Domiphen (bromide)

Domiphen bromide is a cationic active quaternary ammonium salt and also an inhibitor of HERG channels (IC50: 9 nM), aminopeptidase-like enzymes, Escherichia coli alkaline phosphatase, and α-chymotrypsin. Domiphen bromide has multiple activities such as antibacterial, antimalarial, and disinfectant properties, and it is also a synergist of Colistin (HY-113678) . Domiphen bromide can be used as a chemical preservative and a cationic surfactant, and it can also be used in the research of bacterial infectious diseases such as pharyngitis, thrush, and oral ulcers[1][2][3][4][5].

Product Specifications

CAS Number

[538-71-6]

UNSPSC

12352005

Hazard Statement

H315, H319, H335

Target

Bacterial; Parasite; Phosphatase; Potassium Channel

Type

Reference compound

Related Pathways

Anti-infection; Membrane Transporter/Ion Channel; Metabolic Enzyme/Protease

Field of Research

Infection; Inflammation/Immunology

Assay Protocol

https://www.medchemexpress.com/Domiphen-bromide.html

Purity

99.61

Solubility

DMSO : 100 mg/mL (ultrasonic) |H2O : 100 mg/mL (ultrasonic)

Smiles

CCCCCCCCCCCC[N+](C)(C)CCOC1=CC=CC=C1.[Br-]

Molecular Formula

C22H40BrNO

Molecular Weight

414.46

Precautions

H315, H319, H335

References & Citations

[1]Biosca A, et al. Characterization of Domiphen Bromide as a New Fast-Acting Antiplasmodial Agent Inhibiting the Apicoplastidic Methyl Erythritol Phosphate Pathway. Pharmaceutics. 2022 Jun 22;14 (7) :1320.|[2]Chen H, et al. Combining with domiphen bromide restores colistin efficacy against colistin-resistant Gram-negative bacteria in vitro and in vivo. Int J Antimicrob Agents. 2024 Feb;63 (2) :107066.|[3]Long Y, et al. Proarrhythmic effects induced by benzethonium chloride and domiphen bromide in vitro and in vivo. Toxicol Appl Pharmacol. 2021 Nov 15;431:115731.|[4]Long Y, et al. Inhibition of HERG potassium channels by domiphen bromide and didecyl dimethylammonium bromide. Eur J Pharmacol. 2014 Aug 15;737:202-9.|[5]Mäkinen KK, et al. Selective effect of domiphen bromide (dodecyldimethyl (2-phenoxyethyl) ammonium bromide) on some hydrolytic enzymes. Biochim Biophys Acta. 1970 Apr 22;206 (1) :143-51.