Ophiobolin A
Ophiobolin A, a fungal metabolite and a phytotoxin, is a potent and irreversibly inhibitor of calmodulin-activated cyclic nucleotide phosphodiesterase, with an IC50 value of 9 μM. Ophiobolin A antimicrobial and anticancer activity[1].
Product Specifications
CAS Number
4611-05-6
UNSPSC
12352005
Hazard Statement
H301
Target
Phosphodiesterase (PDE)
Type
Natural Products
Related Pathways
Metabolic Enzyme/Protease
Applications
COVID-19-immunoregulation
Field of Research
Cancer; Infection
Assay Protocol
https://www.medchemexpress.com/ophiobolin-a.html
Purity
98.86
Solubility
Methanol : 4 mg/mL (ultrasonic; warming)
Smiles
O=C/C1=C/C[C@]2([H])[C@@](CC[C@@]23O[C@@H](/C=C(C)\C)C[C@@H]3C)(C)C[C@@]4([H])[C@]1([H])C(C[C@]4(O)C)=O
Molecular Formula
C25H36O4
Molecular Weight
400.55
Precautions
H301
References & Citations
[1]Leung PC, et al. Ophiobolin A. A natural product inhibitor of calmodulin. J Biol Chem. 1984 Mar 10;259 (5) :2742-7
Shipping Conditions
Blue Ice
Storage Conditions
-20°C (Powder, protect from light)
Scientific Category
Natural Products
Clinical Information
No Development Reported
Available Sizes
Frequently Asked Questions
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