GW-6604
GW-6604 is an ALK5 inhibitor with an IC50 value of 140 nM for inhibiting its autophosphorylation, and can be used in the study of liver fibrosis[1].
Product Specifications
CAS Number
[452342-37-9]
UNSPSC
12352005
Hazard Statement
H302, H315, H319
Target
TGF-β Receptor
Type
Reference compound
Related Pathways
TGF-beta/Smad
Applications
Metabolism-protein/nucleotide metabolism
Field of Research
Metabolic Disease
Assay Protocol
https://www.medchemexpress.com/gw-6604.html
Purity
98.0
Solubility
DMSO : 100 mg/mL (ultrasonic)
Smiles
C1(C2=NNC=C2C3=CC(C4=CC=CC=C4)=NC=C3)=CC=CC=N1
Molecular Formula
C19H14N4
Molecular Weight
298.34
Precautions
H302, H315, H319
References & Citations
[1]Anne-Charlotte de Gouville, et al. Inhibition of TGF-beta signaling by an ALK5 inhibitor protects rats from dimethylnitrosamine-induced liver fibrosis. Br J Pharmacol. 2005 May;145 (2) :166-77.
Shipping Conditions
Room Temperature
Storage Conditions
4°C (Powder, protect from light)
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Available Sizes
Curated Selection
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