Jingzhaotoxin-34
Jingzhaotoxin-34, a 35-residue polypeptide, is a neurotoxin. Jingzhaotoxin-34 inhibits tetrodotoxin-sensitive (TTX-S) sodium currents (IC50 of ~85 nM) while having no significant effects on tetrodotoxin-resistant (TTX-R) sodium currents on rat dorsal root ganglion neurons[1].
Product Specifications
UNSPSC
12352209
Target
Sodium Channel
Type
Peptides
Related Pathways
Membrane Transporter/Ion Channel
Applications
Neuroscience-Neuromodulation
Field of Research
Neurological Disease
Assay Protocol
https://www.medchemexpress.com/jingzhaotoxin-34.html
Solubility
10 mM in DMSO
Smiles
O=C(CN)N[C@H](C(NCC(N[C@H](C(N[C@H](C(N[C@H](C(N[C@H](C(N1[C@H](C(N[C@H](C(NC(C(N[C@H](C(NC(C(NC(C(N2C(C(N[C@H]3CSSC[C@H](NC4=O)C(N[C@H](C(N[C@H](C(N[C@H](C(N5[C@H](C(O)=O)CCC5)=O)CO)=O)CC6=CNC7=CC=CC=C67)=O)[C@H](CC)C)=O)=O)CCC2)=O)CCCCN)=O)CCC(O)=O)=O)[C@@H](C)O)=O)CO)=O)CSSC[C@H](NC8=O)C(N[C@H](C(N9[C@H](C(N[C@H](C(N[C@H](C(N[C@H](C(N[C@H]4CC%10=CNC%11=CC=CC=C%10%11)=O)CCCCN)=O)[C@H](CC)C)=O)C)=O)CCC9)=O)CCC(N)=O)=O)=O)CCC1)=O)CO)=O)CC%12=CNC%13=CC=CC=C%12%13)=O)CCSC)=O)[C@@H](C)O)=O)=O)CSSC[C@H](NC3=O)C(N[C@H](C(N[C@H](C(N[C@H](C(N[C@H]8CO)=O)CC%14=CC=CC=C%14)=O)CC(N)=O)=O)CC(O)=O)=O
Molecular Formula
C154H219N39O45S7
Molecular Weight
3561.08
References & Citations
[1]Jinjun Chen, et al. Expression and characterization of jingzhaotoxin-34, a novel neurotoxin from the venom of the tarantula Chilobrachys jingzhao. Peptides. 2009 Jun;30 (6) :1042-8.
Shipping Conditions
Room temperature
Scientific Category
Peptides
Clinical Information
No Development Reported
Frequently Asked Questions
More Discoveries
Explore Other Products
Browse additional items from our catalog
