Atuliflapon
Product Specifications
Product Name Alternative
AZD5718
UNSPSC Description
Atuliflapon (AZD5718) is an orally active inhibitor of FLAP (5?Lipoxygenase activating protein), with an IC50 of 2 nM. Atuliflapon is used in the study for coronary artery disease[1].
Target Antigen
FLAP
Type
Reference compound
Related Pathways
Immunology/Inflammation
Field of Research
Cardiovascular Disease
Assay Protocol
https://www.medchemexpress.com/azd5718.html
Purity
98.97
Solubility
DMSO : 125 mg/mL (ultrasonic)
Smiles
O=C([C@H]1[C@H](C(C2=CC=C(C3=NNC(C)=C3)C=C2)=O)CCCC1)NC4=C(N(N=C4)CCN5)C5=O
Molecular Weight
446.50
References & Citations
[1]Daniel Pettersen, et al. Discovery and Early Clinical Development of an Inhibitor of 5-Lipoxygenase Activating Protein (AZD5718) for Treatment of Coronary Artery Disease. J Med Chem. 2019 May 9;62(9):4312-4324.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Product Datasheet
http://file.medchemexpress.com/batch_PDF/HY-122908/Atuliflapon-DataSheet-MedChemExpress.pdf
Product MSDS
http://file.medchemexpress.com/batch_PDF/HY-122908/Atuliflapon-SDS-MedChemExpress.pdf
Clinical Information
Phase 2
CAS Number
2041075-86-7
Available Sizes
Curated Selection
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