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Halociline

Halociline, a derivative of alkaloids, that can be isolated from the marine fungus Penicillium griseofulvum. Halociline targets MAPK1, MMP-9, and PIK3CA in gastric cancer cells, potentially mediated by diverse pathways including cancer, lipid metabolism, atherosclerosis, and EGFR tyrosine kinase inhibitor resistance. Halociline possesses antimicrobial, antioxidant and biofilm inhibitory activities[1][2].

Product Specifications

CAS Number

2977255-36-8

UNSPSC

12352005

Target

MMP; p38 MAPK

Type

Natural Products

Related Pathways

MAPK/ERK Pathway; Metabolic Enzyme/Protease

Applications

COVID-19-immunoregulation

Field of Research

Cancer; Infection; Inflammation/Immunology

Assay Protocol

https://www.medchemexpress.com/halociline.html

Solubility

10 mM in DMSO

Smiles

CC1=C(C=C(C=C1C(C(O)C)C)O)N

Molecular Formula

C11H17NO2

Molecular Weight

195.26

References & Citations

[1]Mohamed M M Abdel Razek, et al. A New Phenolic Alkaloid from Halocnemum strobilaceum Endophytes: Antimicrobial, Antioxidant and Biofilm Inhibitory Activities. Chem Biodivers. 2020 Oct;17 (10) :e2000496.|[2]Xiangru Zha, et al. Network pharmacology, molecular docking, and molecular dynamics simulation analysis reveal the molecular mechanism of halociline against gastric cancer. Mol Divers. 2024 Mar 19.

Shipping Conditions

Room temperature

Scientific Category

Natural Products

Clinical Information

No Development Reported

Isoform

MMP-9; p38 MAPK

Frequently Asked Questions

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