BMS905

BMS905 is an orally active TLR7 and TLR8 dual inhibitor (IC50s: 0.7 and 3.2 nM respectively) . BMS905 inhibits TLR7 or TLR8 induced IL-6 production in human/mouse whole blood. BMS905 can be used for research of lupus[1].

Product Specifications

CAS Number

[2205846-49-5]

UNSPSC

12352005

Target

Toll-like Receptor (TLR)

Type

Reference compound

Related Pathways

Immunology/Inflammation

Applications

COVID-19-immunoregulation

Field of Research

Inflammation/Immunology

Assay Protocol

https://www.medchemexpress.com/bms905.html

Purity

98.25

Solubility

DMSO : 12.5 mg/mL (ultrasonic; warming; heat to 60°C)

Smiles

CC1=NC(C)=CC(C2=C(C(C)C)C3=C(C=CC(C4CCNCC4)=C3)N2)=C1

Molecular Formula

C23H29N3

Molecular Weight

347.50

References & Citations

[1]Sreekantha RK, et al. Identification of 2-Pyridinylindole-Based Dual Antagonists of Toll-like Receptors 7 and 8 (TLR7/8) . ACS Med Chem Lett. 2022 Apr 25;13 (5) :812-818.