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PROTAC B-Raf degrader 1

Product Specifications

UNSPSC Description

PROTAC B-Raf degrader 1 (compound 2) is a proteolysis targeting chimera (PROTAC) for the degradation of B-Raf based on Cereblon ligand with anti-cancer activity[1].

Target Antigen

PROTACs; Raf

Type

Reference compound

Related Pathways

MAPK/ERK Pathway;PROTAC

Applications

Cancer-Kinase/protease

Field of Research

Cancer

Assay Protocol

https://www.medchemexpress.com/PROTAC_B-Raf_degrader_1.html

Purity

99.78

Solubility

DMSO : 25 mg/mL (ultrasonic)

Smiles

O=C(NC1=CC=CC(C(N2C(CC3)C(NC3=O)=O)=O)=C1C2=O)CNC(CNC4=CC(CS(=O)(/C=C/C5=C(OC)C=C(OC)C=C5OC)=O)=CC=C4OC)=O

Molecular Weight

763.77

References & Citations

[1]Chen H, et al. Pomalidomide hybrids act as proteolysis targeting chimeras: Synthesis, anticancer activity and B-Raf degradation. Bioorg Chem. 2019 Mar 19;87:191-199.

Shipping Conditions

Blue Ice

Storage Conditions

-20°C (Powder, stored under nitrogen)

Product Datasheet

http://file.medchemexpress.com/batch_PDF/HY-111758/PROTAC-B-Raf-degrader-1-DataSheet-MedChemExpress.pdf

Product MSDS

http://file.medchemexpress.com/batch_PDF/HY-111758/PROTAC-B-Raf-degrader-1-SDS-MedChemExpress.pdf

Clinical Information

No Development Reported

CAS Number

2364367-27-9

Available Sizes

Curated Selection

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