5-cis Carbaprostacyclin

5-cis Carbaprostacyclin is a stable analog of PGI2 based on Carbaprostacyclin (HY-112322) . Carbacyclin is a PGI2 receptor agonist and vasodilator that activates PPARδ. 5-cis Carbaprostacyclin induces relaxation of pulmonary vascular tone[1][2].

Product Specifications

CAS Number

[69609-77-4]

UNSPSC

12352211

Hazard Statement

H302+H312+H332

Target

Drug Derivative; PPAR; Prostaglandin Receptor

Type

Reference compound

Related Pathways

Cell Cycle/DNA Damage; GPCR/G Protein; Metabolic Enzyme/Protease; Others; Vitamin D Related/Nuclear Receptor

Applications

Neuroscience-Neuromodulation

Field of Research

Cardiovascular Disease

Assay Protocol

https://www.medchemexpress.com/5-cis-carbaprostacyclin.html

Solubility

10 mM in DMSO

Smiles

CCCCC[C@H](O)/C=C/[C@@H]1[C@]2([H])[C@@](C[C@H]1O)([H])C/C(C2)=C/CCCC(O)=O

Molecular Formula

C21H34O4

Molecular Weight

350.49

Precautions

P261-P264-P270-P271-P280-P302+P352-P304+P340-P330-P362+P364-P501

References & Citations

[1]Norel X, et al. Vasoconstriction induced by activation of EP1 and EP3 receptors in human lung: effects of ONO-AE-248, ONO-DI-004, ONO-8711 or ONO-8713. Prostaglandins Other Lipid Mediat. 2004 Oct;74 (1-4) :101-12.|[2]Kurtz M, et al. Carbaprostacyclin, a PPARdelta agonist, ameliorates excess lipid accumulation in diabetic rat placentas. Life Sci. 2010 May 22;86 (21-22) :781-90.