DOV-216,303 (Free Base)
DOV-216,303 (Free Base) is a potent triple serotonin, norepinephrine, and dopamine reuptake inhibitor, with IC50 values of 14 nM, 20 nM and 78 nM for hSERT, hNET and hDAT, respectively. Has antidepressant-like effects and increases monoamine release in the prefrontal cortex of olfactory bulbectomized (OBX) rats[1][2].
Product Specifications
CAS Number
[66504-40-3]
UNSPSC
12352005
Hazard Statement
H302, H315, H319
Target
Dopamine Transporter; Serotonin Transporter
Type
Reference compound
Related Pathways
Neuronal Signaling
Applications
Neuroscience-Neuromodulation
Field of Research
Neurological Disease
Assay Protocol
https://www.medchemexpress.com/DOV-216,303_Free_Base.html
Purity
98.17
Solubility
DMSO : ≥ 125 mg/mL|Ethanol : 100 mg/mL (ultrasonic)
Smiles
ClC1=C(Cl)C=C(C=C1)C12CC1CNC2
Molecular Formula
C11H11Cl2N
Molecular Weight
228.12
Precautions
H302, H315, H319
References & Citations
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Available Sizes
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