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DOV-216,303 (Free Base)

DOV-216,303 (Free Base) is a potent triple serotonin, norepinephrine, and dopamine reuptake inhibitor, with IC50 values of 14 nM, 20 nM and 78 nM for hSERT, hNET and hDAT, respectively. Has antidepressant-like effects and increases monoamine release in the prefrontal cortex of olfactory bulbectomized (OBX) rats[1][2].

Product Specifications

CAS Number

66504-40-3

UNSPSC

12352005

Hazard Statement

H302, H315, H319

Target

Dopamine Transporter; Serotonin Transporter

Type

Reference compound

Related Pathways

Neuronal Signaling

Applications

Neuroscience-Neuromodulation

Field of Research

Neurological Disease

Assay Protocol

https://www.medchemexpress.com/DOV-216,303_Free_Base.html

Purity

98.17

Solubility

DMSO : ≥ 125 mg/mL|Ethanol : 100 mg/mL (ultrasonic)

Smiles

ClC1=C(Cl)C=C(C=C1)C12CC1CNC2

Molecular Formula

C11H11Cl2N

Molecular Weight

228.12

Precautions

H302, H315, H319

References & Citations

[1]Popik P, et al. Pharmacological profile of the "triple" monoamine neurotransmitter uptake inhibitor, DOV 102,677. Cell Mol Neurobiol. 2006 Jul-Aug;26 (4-6) :857-73.

Shipping Conditions

Room Temperature

Storage Conditions

-20°C, 3 years; 4°C, 2 years (Powder)

Scientific Category

Reference compound1

Clinical Information

No Development Reported

Available Sizes

Frequently Asked Questions

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