Endothelin-1 (1-31) (Human)

Endothelin-1 (1-31) (Human) is a potent vasoconstrictor and hypertensive agent. Endothelin-1 (1-31) (Human) is derived from the selective hydrolysis of big ET-1 by chymase[1].

Product Specifications

CAS Number

[133972-52-8]

UNSPSC

12352209

Target

ERK

Type

Peptides

Related Pathways

MAPK/ERK Pathway; Stem Cell/Wnt

Applications

Neuroscience-Neuromodulation

Field of Research

Cardiovascular Disease

Assay Protocol

https://www.medchemexpress.com/endothelin-1-1-31-human.html

Purity

99.73

Solubility

DMSO : 33.33 mg/mL (ultrasonic)

Smiles

O=C(N[C@@H](CO)C(N[C@@H](CSSC[C@@H](C(N[C@@H](C(C)C)C(N[C@@H](CC1=CC=C(C=C1)O)C(N[C@H]2CC3=CC=CC=C3)=O)=O)=O)NC4=O)C(N[C@@H](CO)C(N[C@@H](CO)C(N[C@@H](CC(C)C)C(N[C@@H](CCSC)C(N[C@@H](CC(O)=O)C(N[C@@H](CCCCN)C(N[C@H]4CCC(O)=O)=O)=O)=O)=O)=O)=O)=O)=O)[C@H](CSSC[C@@H](C(N[C@@H](CC5=CNC=N5)C(N[C@@H](CC(C)C)C(N[C@@H](CC(O)=O)C(N[C@@H]([C@@H](C)CC)C(N[C@@H]([C@@H](C)CC)C(N[C@@H](CC6=CNC7=CC=CC=C67)C(N[C@@H](C(C)C)C(N[C@@H](CC(N)=O)C(N[C@@H]([C@H](O)C)C(N8[C@@H](CCC8)C(N[C@@H](CCC(O)=O)C(N[C@@H](CC9=CNC=N9)C(N[C@@H](C(C)C)C(N[C@@H](C(C)C)C(N%10[C@@H](CCC%10)C(N[C@@H](CC%11=CC=C(C=C%11)O)C(O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)NC2=O)N

Molecular Formula

C162H236N38O47S5

Molecular Weight

3628.16

References & Citations

[1]Matsumoto T, et al. Gender differences in vascular reactivity to endothelin-1 (1-31) in mesenteric arteries from diabetic mice. Peptides. 2008 Aug;29 (8) :1338-46.|[2]Yoshizumi M, et al. Effect of endothelin-1 (1-31) on human mesangial cell proliferation. Jpn J Pharmacol. 2000 Oct;84 (2) :146-55.