ZXH-1-161

ZXH-1-161 is a potent CRBN modulator that selectively induces the degradation of GSPT1 in a CRBN-dependent manner. ZXH-1-161 can inhibit the proliferation of multiple myeloma cells and exhibits antitumor activity[1].

Product Specifications

CAS Number

[2407654-51-5]

UNSPSC

12352005

Hazard Statement

H302, H315, H319, H335

Target

Molecular Glues

Type

Reference compound

Related Pathways

PROTAC

Applications

Cancer-programmed cell death

Field of Research

Cancer

Assay Protocol

https://www.medchemexpress.com/zxh-1-161.html

Concentration

10mM

Purity

98.92

Solubility

DMSO : 250 mg/mL (ultrasonic)

Smiles

O=C1NC(C(CC1)N2C(C3=C(C2)C(NC4=NC(NC5=CC=C6C(CCC6)=C5)=NC=C4)=CC=C3)=O)=O

Molecular Formula

C26H24N6O3

Molecular Weight

468.51

Precautions

H302, H315, H319, H335

References & Citations

[1]Powell CE, et al. Selective Degradation of GSPT1 by Cereblon Modulators Identified via a Focused Combinatorial Library. ACS Chem Biol. 2020 Oct 16;15 (10) :2722-2730.

Shipping Conditions

Room Temperature

Storage Conditions

-20°C, 3 years; 4°C, 2 years (Powder)

Scientific Category

Reference compound1

Clinical Information

No Development Reported

Isoform

Cereblon

Available Sizes

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