ZXH-1-161
ZXH-1-161 is a potent CRBN modulator that selectively induces the degradation of GSPT1 in a CRBN-dependent manner. ZXH-1-161 can inhibit the proliferation of multiple myeloma cells and exhibits antitumor activity[1].
Product Specifications
CAS Number
[2407654-51-5]
UNSPSC
12352005
Hazard Statement
H302, H315, H319, H335
Target
Molecular Glues
Type
Reference compound
Related Pathways
PROTAC
Applications
Cancer-programmed cell death
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/zxh-1-161.html
Concentration
10mM
Purity
98.92
Solubility
DMSO : 250 mg/mL (ultrasonic)
Smiles
O=C1NC(C(CC1)N2C(C3=C(C2)C(NC4=NC(NC5=CC=C6C(CCC6)=C5)=NC=C4)=CC=C3)=O)=O
Molecular Formula
C26H24N6O3
Molecular Weight
468.51
Precautions
H302, H315, H319, H335
References & Citations
[1]Powell CE, et al. Selective Degradation of GSPT1 by Cereblon Modulators Identified via a Focused Combinatorial Library. ACS Chem Biol. 2020 Oct 16;15 (10) :2722-2730.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
Cereblon
Available Sizes
More Discoveries
Explore Other Products
Browse additional items from our catalog
125612 100 µg
CYTH1 (Cytohesin-1, PH, SEC7 and Coiled-coil Domain-containing Protein 1, SEC7 Homolog B2-1, D17S811E, PSCD1)
Sign In for Pricing
View Details 
LV809677 1.0 µg DNA
C6orf115 Lentiviral Vector (Human) (UbC) (pLenti-GIII-UbC)
Sign In for Pricing
View Details MBS1267034-01 0.01 mg Plasmid + 0.2 mL Glycerol-Stock
C14orf45 cDNA Clone
Sign In for Pricing
View Details