ZXH-1-161
ZXH-1-161 is a potent CRBN modulator that selectively induces the degradation of GSPT1 in a CRBN-dependent manner. ZXH-1-161 can inhibit the proliferation of multiple myeloma cells and exhibits antitumor activity[1].
Product Specifications
CAS Number
[2407654-51-5]
UNSPSC
12352005
Hazard Statement
H302, H315, H319, H335
Target
Molecular Glues
Type
Reference compound
Related Pathways
PROTAC
Applications
Cancer-programmed cell death
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/zxh-1-161.html
Concentration
10mM
Purity
98.92
Solubility
DMSO : 250 mg/mL (ultrasonic)
Smiles
O=C1NC(C(CC1)N2C(C3=C(C2)C(NC4=NC(NC5=CC=C6C(CCC6)=C5)=NC=C4)=CC=C3)=O)=O
Molecular Formula
C26H24N6O3
Molecular Weight
468.51
Precautions
H302, H315, H319, H335
References & Citations
[1]Powell CE, et al. Selective Degradation of GSPT1 by Cereblon Modulators Identified via a Focused Combinatorial Library. ACS Chem Biol. 2020 Oct 16;15 (10) :2722-2730.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
Cereblon
Available Sizes
Curated Selection
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