(Rac)-SCH 563705
Product Specifications
UNSPSC Description
(Rac)-SCH 563705 is a racemic mixture of SCH 563705 (HY-10011). SCH 563705 (compound 16) is a potent and orally active CXCR2 and CXCR1 antagonist with IC50 values of 1.3 nM and 7.3 nM and Ki values of 1 nM and 3 nM, respectively[1][2].
Target Antigen
CXCR
Type
Reference compound
Related Pathways
GPCR/G Protein;Immunology/Inflammation
Field of Research
Endocrinology; Inflammation/Immunology
Assay Protocol
https://www.medchemexpress.com/rac-sch-563705.html
Purity
99.78
Solubility
DMSO : 200 mg/mL (ultrasonic)
Smiles
O=C(C(NC1=CC=CC(C(N(C)C)=O)=C1O)=C2NC(CC)C3=CC(C(C)C)=CO3)C2=O
Molecular Weight
425.48
References & Citations
[1]Min S H, et al. Pharmacological targeting reveals distinct roles for CXCR2/CXCR1 and CCR2 in a mouse model of arthritis[J]. Biochemical and biophysical research communications, 2010, 391(1): 1080-1086.|[2]Chao J, et al. C (4)-alkyl substituted furanyl cyclobutenediones as potent, orally bioavailable CXCR2 and CXCR1 receptor antagonists[J]. Bioorganic & medicinal chemistry letters, 2007, 17(13): 3778-3783.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Product Datasheet
http://file.medchemexpress.com/batch_PDF/HY-10011B/Rac-SCH-563705-DataSheet-MedChemExpress.pdf
Product MSDS
http://file.medchemexpress.com/batch_PDF/HY-10011B/Rac-SCH-563705-SDS-MedChemExpress.pdf
Clinical Information
No Development Reported
CAS Number
2701435-64-3
Available Sizes
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