(Rac) -SCH 563705

(Rac) -SCH 563705 is a racemic mixture of SCH 563705 (HY-10011) . SCH 563705 (compound 16) is a potent and orally active CXCR2 and CXCR1 antagonist with IC50 values of 1.3 nM and 7.3 nM and Ki values of 1 nM and 3 nM, respectively[1][2].

Product Specifications

CAS Number

[2701435-64-3]

UNSPSC

12352005

Target

CXCR

Type

Reference compound

Related Pathways

GPCR/G Protein; Immunology/Inflammation

Field of Research

Endocrinology; Inflammation/Immunology

Assay Protocol

https://www.medchemexpress.com/rac-sch-563705.html

Purity

99.78

Solubility

DMSO : 200 mg/mL (ultrasonic)

Smiles

O=C(C(NC1=CC=CC(C(N(C)C)=O)=C1O)=C2NC(CC)C3=CC(C(C)C)=CO3)C2=O

Molecular Formula

C23H27N3O5

Molecular Weight

425.48

References & Citations

[1]Min S H, et al. Pharmacological targeting reveals distinct roles for CXCR2/CXCR1 and CCR2 in a mouse model of arthritis[J]. Biochemical and biophysical research communications, 2010, 391 (1) : 1080-1086.|[2]Chao J, et al. C (4) -alkyl substituted furanyl cyclobutenediones as potent, orally bioavailable CXCR2 and CXCR1 receptor antagonists[J]. Bioorganic & medicinal chemistry letters, 2007, 17 (13) : 3778-3783.