Cathepsin L-IN-5

Cathepsin L-IN-5 (D6-3) is a potent Cathepsin L (CatL) inhibitor with an IC50 of 0.27 nM. Cathepsin L-IN-5 effectively blocks the CatL function and substantially hinders the entry of the SARS-CoV-2 pseudovirus to cells by inhibiting the cleavage of the spike protein. Cathepsin L-IN-5 can be utilized in SARS-CoV-2 research[1].

Product Specifications

UNSPSC

12352211

Target

Cathepsin

Type

Reference compound

Related Pathways

Metabolic Enzyme/Protease

Applications

COVID-19-anti-virus

Field of Research

Infection

Assay Protocol

https://www.medchemexpress.com/cathepsin-l-in-5.html

Smiles

O=C(C1=C2C=CC=CC2=CC=C1)N[C@H](C(N[C@@H](CC3=CC=CC=C3)C(CCl)=O)=O)CC4=CC=C(C=C4)F

Molecular Formula

C30H26ClFN2O3

Molecular Weight

516.99

References & Citations

[1]Deng W, et al. Peptidomimetic Analogues Act as Effective Inhibitors against SARS-CoV-2 by Blocking the Function of Cathepsin L. J Med Chem. 2024 Oct 10;67 (19) :17124-17143.