Cathepsin L-IN-5
Cathepsin L-IN-5 (D6-3) is a potent Cathepsin L (CatL) inhibitor with an IC50 of 0.27 nM. Cathepsin L-IN-5 effectively blocks the CatL function and substantially hinders the entry of the SARS-CoV-2 pseudovirus to cells by inhibiting the cleavage of the spike protein. Cathepsin L-IN-5 can be utilized in SARS-CoV-2 research[1].
Product Specifications
UNSPSC
12352211
Target
Cathepsin
Type
Reference compound
Related Pathways
Metabolic Enzyme/Protease
Applications
COVID-19-anti-virus
Field of Research
Infection
Assay Protocol
https://www.medchemexpress.com/cathepsin-l-in-5.html
Smiles
O=C(C1=C2C=CC=CC2=CC=C1)N[C@H](C(N[C@@H](CC3=CC=CC=C3)C(CCl)=O)=O)CC4=CC=C(C=C4)F
Molecular Formula
C30H26ClFN2O3
Molecular Weight
516.99
References & Citations
[1]Deng W, et al. Peptidomimetic Analogues Act as Effective Inhibitors against SARS-CoV-2 by Blocking the Function of Cathepsin L. J Med Chem. 2024 Oct 10;67 (19) :17124-17143.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
Cathepsin L
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