Thioredoxin Glutathione Reductase (Schistosoma mansoni)

<strong>Thioredoxin Glutathione Reductase (Schistosoma mansoni)</strong>_x000D_ <strong>Catalog number:</strong> B2016748_x000D_ <strong>Lot number:</strong> Batch Dependent_x000D_ <strong>Expiration Date:</strong> Batch dependent_x000D_ <strong>Amount:</strong> 50 µg_x000D_ <strong>Molecular Weight or Concentration:</strong> N/A_x000D_ <strong>Supplied as:</strong> Solution_x000D_ <strong>Applications:</strong> a molecular tool for various biochemical applications_x000D_ <strong>Storage:</strong> −20°C_x000D_ <strong>Keywords:</strong> TGR_x000D_ <strong>Grade:</strong> Biotechnology grade. All products are highly pure. All solutions are made with Type I ultrapure water (resistivity &gt;18 MΩ-cm) and are filtered through 0.22 um._x000D_ _x000D_ <strong>References:</strong>_x000D_ 1: Song L, Li J, Xie S, Qian C, Wang J, Zhang W, Yin X, Hua Z, Yu C. Thioredoxin_glutathione_reductase as a novel drug target: evidence from Schistosoma japonicum PLoS One. 2012;7(2):e31456._x000D_ 2: Kuntz AN, Davioud-Charvet E, Sayed AA, Califf LL, Dessolin J, Arnér ES, Williams DL. Thioredoxin_glutathione_reductase from Schistosoma_mansoni: an essential parasite enzyme and a key drug target PLoS Med. 2007 Jun;4(6):e206._x000D_ 3: Alger HM, Williams DL. The disulfide redox system of Schistosoma_mansoni and the importance of a multifunctional enzyme, thioredoxin glutathione reductase Mol Biochem Parasitol. 2002 Apr 30;121(1):129-39._x000D_ 4: Maggioli G, Silveira F, Martín-Alonso JM, Salinas G, Carmona C, Parra F. A recombinant thioredoxin-glutathione_reductase from Fasciola hepatica induces a protective response in rabbits Exp Parasitol. 2011 Dec;129(4):323-30._x000D_ 5: Lea WA, Jadhav A, Rai G, Sayed AA, Cass CL, Inglese J, Williams DL, Austin CP, Simeonov A. A 1,536-well-based kinetic HTS assay for inhibitors of Schistosoma mansoni thioredoxin glutathione reductase Assay Drug Dev Technol. 2008 Aug;6(4):551-5._x000D_ 6: Treger RS, Cook AG, Rai G, Maloney DJ, Simeonov A, Jadhav A, Thomas CJ, Williams DL, Cappello M, Vermeire JJ. Oxadiazole 2-oxides are toxic to the human hookworm, Ancylostoma ceylanicum, however glutathione_reductase is not the primary target Int J Parasitol Drugs Drug Resist. 2012 Dec 1;2:171-177._x000D_ 7: Guglielmo S, Cortese D, Vottero F, Rolando B, Kommer VP, Williams DL, Fruttero R, Gasco A. New praziquantel derivatives containing NO-donor furoxans and related furazans as active agents against Schistosoma mansoni Eur J Med Chem. 2014 Sep 12;84:135-45._x000D_ 8: Smith MM, Alt TB, Williams DL, Moran GR. Descriptive Analysis of Transient-State Observations for Thioredoxin/Glutathione Reductase (Sec597Cys) from Schistosoma_mansoni Biochemistry. 2023 May 2;62(9):1497-1508._x000D_ 9: Petukhova VZ, Aboagye SY, Ardini M, Lullo RP, Fata F, Byrne ME, Gabriele F, Martin LM, Harding LNM, Gone V, Dangi B, Lantvit DD, Nikolic D, Ippoliti R, Effantin G, Ling WL, Johnson JJ, Thatcher GRJ, Angelucci F, Williams DL, Petukhov PA. Non-covalent inhibitors of thioredoxin_glutathione reductase with schistosomicidal activity in vivo Nat Commun. 2023 Jun 22;14(1):3737._x000D_ <a href="https://pubmed.ncbi.nlm.nih.gov/37780207">10: Smith MM, Moran GR. Assigning function to active site residues of Schistosoma mansoni thioredoxin/glutathione reductase from analysis of transient state reductive half-reactions with variant forms of the enzyme Front Mol Biosci. 2023 Sep 13;10:1258333. </a>_x000D_ _x000D_ <strong>Products Related to Thioredoxin Glutathione Reductase (Schistosoma mansoni) can be found at</strong> <a href="https://moleculardepot.com/product-category/Proteins/"> Proteins</a>