Sarecycline (hydrochloride)

Sarecycline hydrochloride is an orally active narrow-spectrum tetracycline derivative antibiotic. Sarecycline hydrochloride has anti-inflammatory activity. Sarecycline hydrochloride inhibits the activity of Gram-positive bacteria and several types of keratobacterium acnes. Sarecycline hydrochloride interferes with tRNA accommodation and tethers mRNA to the 70S ribosome. Sarecycline hydrochloride can be used to study moderate to severe acne [1][2][3][4][5][6].

Product Specifications

CAS Number

[1035979-44-2]

Product Name Alternative

P-005672 (hydrochloride)

UNSPSC

12352005

Hazard Statement

H302, H315, H319, H335

Target

Antibiotic; Bacterial; DNA/RNA Synthesis

Type

Reference compound

Related Pathways

Anti-infection; Cell Cycle/DNA Damage

Applications

COVID-19-immunoregulation

Field of Research

Infection

Assay Protocol

https://www.medchemexpress.com/sarecycline-hydrochloride.html

Concentration

10mM

Purity

99.78

Solubility

DMSO : 100 mg/mL (ultrasonic)

Smiles

[H]Cl.O[C@]12[C@](C[C@@]3([H])C(C(C4=C(O)C=CC(CN(C)OC)=C4C3)=O)=C2O)([H])[C@@H](C(O)=C(C1=O)C(N)=O)N(C)C

Molecular Formula

C24H30ClN3O8

Molecular Weight

523.96

Precautions

H302, H315, H319, H335

References & Citations

[1]Zhanel G, Critchley I, Lin LY, Alvandi N. Microbiological Profile of Sarecycline, a Novel Targeted Spectrum Tetracycline for the Treatment of Acne Vulgaris. Antimicrob Agents Chemother. 2018;63 (1) :e01297-18. Published 2018 Dec 21.|[2]Moore AY, Charles JEM, Moore S. Sarecycline: a narrow spectrum tetracycline for the treatment of moderate-to-severe acne vulgaris. Future Microbiol. 2019;14 (14) :1235-1242.|[3]Batool Z, et al. Sarecycline interferes with tRNA accommodation and tethers mRNA to the 70S ribosome. Proc Natl Acad Sci U S A. 2020;117 (34) :20530-20537.|[4]Butler MS, et al. Antibiotics in the clinical pipeline in 2013. J Antibiot (Tokyo) . 2013 Oct;66 (10) :571-91.|[5]Moore AY, et al. Sarecycline: a narrow spectrum tetracycline for the treatment of moderate-to-severe acne vulgaris. Future Microbiol. 2019 Sep;14 (14) :1235-1242. |[6]Bunick CG, et al. Antibacterial Mechanisms and Efficacy of Sarecycline in Animal Models of Infection and Inflammation. Antibiotics (Basel) . 2021 Apr 15;10 (4) :439.

Shipping Conditions

Room Temperature

Storage Conditions

4°C (Powder, sealed storage, away from moisture)

Scientific Category

Reference compound1

Clinical Information

Launched

Isoform

Tetracycline

Citation 01

Microbiol Spectr. 2023 Feb 14;11 (1) :e0323822.|Microbiol Spectr. 2023 Jun 15;11 (3) :e0071823.|Pharmaceutics. 2021 Dec 5;13 (12) :2085.|Clin Exp Pharmacol Physiol. 2023 Jul;50 (7) :604-609.