GPX4-IN-5

GPX4-IN-5 is a covalent inhibitor of GPX4 (IC50: 0.12 μM) . GPX4-IN-5 can induce ferroptosis and has anti-tumor effects. GPX4-IN-5 can be used in the study of triple-negative breast cancer (TNBC) [1].

Product Specifications

CAS Number

[2922824-09-5]

UNSPSC

12352005

Target

Ferroptosis; Glutathione Peroxidase

Type

Reference compound

Related Pathways

Apoptosis; Metabolic Enzyme/Protease

Applications

Cancer-programmed cell death

Field of Research

Cancer

Assay Protocol

https://www.medchemexpress.com/gpx4-in-5.html

Purity

99.90

Solubility

DMSO : 100 mg/mL (ultrasonic)

Smiles

COC1=CC(N(C2=CC3=C(OCCO3)C=C2)C(CCl)=O)=CC(OC)=C1F

Molecular Formula

C18H17ClFNO5

Molecular Weight

381.78

References & Citations

[1]Chen T, et al. Discovery of Novel Potent Covalent Glutathione Peroxidase 4 Inhibitors as Highly Selective Ferroptosis Inducers for the Treatment of Triple-Negative Breast Cancer. J Med Chem. 2023 Jul 27;66 (14) :10036-10059.