Belumosudil

Belumosudil (KD025) is a selective inhibitor of ROCK2 with IC50s of 105 nM and 24 μM for ROCK2 and ROCK1, respectively. Anti-fibrotic properties[1].

Product Specifications

CAS Number

[911417-87-3]

Product Name Alternative

KD025; SLx-2119

UNSPSC

12352005

Hazard Statement

H302, H315, H319, H335

Target

ROCK

Type

Reference compound

Related Pathways

Cell Cycle/DNA Damage; Cytoskeleton; Stem Cell/Wnt; TGF-beta/Smad

Applications

Cancer-Kinase/protease

Field of Research

Inflammation/Immunology; Cancer

Assay Protocol

https://www.medchemexpress.com/SLx-2119.html

Purity

99.83

Solubility

DMSO : 23.33 mg/mL (ultrasonic; warming; heat to 60°C) |H2O : < 0.1 mg/mL (ultrasonic; warming; heat to 80°C)

Smiles

O=C(NC(C)C)COC1=CC=CC(C2=NC(NC3=CC4=C(NN=C4)C=C3)=C5C=CC=CC5=N2)=C1

Molecular Formula

C26H24N6O2

Molecular Weight

452.51

Precautions

H302, H315, H319, H335

References & Citations

[1]Boerma, M., et al. Comparative gene expression profiling in three primary human cell lines after treatment with a novel inhibitor of Rho kinase. Blood Coagul Fibrinolysis. 2008 Oct;19 (7) :709-18.|[2]Lee, J.H., et al. Selective ROCK2 Inhibition In Focal Cerebral Ischemia. Ann Clin Transl Neurol. 2014 Jan 1;1 (1) :2-14.