BW-180C

BW-180C ([D-Ala2, D-Leu5]-Enkephalin; DADLE) is an δ opioid receptor (DOR) agonist, which belongs to the enkephalin family. Neuroprotective agent. BW-180C reversibly inhibits cellular transcription in neurons without causing cell injury[1].

Product Specifications

CAS Number

[63631-40-3]

Product Name Alternative

[D-Ala2, D-Leu5]-Enkephalin; DADLE

UNSPSC

12352209

Target

Opioid Receptor

Type

Peptides

Related Pathways

GPCR/G Protein; Neuronal Signaling

Applications

Neuroscience-Neuromodulation

Field of Research

Neurological Disease

Assay Protocol

https://www.medchemexpress.com/DADLE.html

Purity

99.92

Solubility

DMSO : 250 mg/mL (ultrasonic)

Smiles

CC(C)C[C@H](C(O)=O)NC([C@@H](NC(CNC([C@@H](C)NC([C@@H](N)CC1=CC=C(O)C=C1)=O)=O)=O)CC2=CC=CC=C2)=O

Molecular Formula

C29H39N5O7

Molecular Weight

569.65

References & Citations

[1]Jie Tian, et al. [D-Ala2, D-Leu5] encephalin (DADLE) reversibly inhibits cellular transcription in neurons without causing cell injury. Brain Res. 2014 May 27;1565:1-7.|[2]Kousyou Yamanouchi, et al. [D-Ala2, D-Leu5] enkephalin (DADLE) protects liver against ischemia-reperfusion injury in the rat. J Surg Res. 2003 Sep;114 (1) :72-7.|[3]Zhou Y, et al. DADLE improves hepatic ischemia/reperfusion injury in mice via activation of the Nrf2/HO‑1 pathway. Mol Med Rep. 2017 Nov;16 (5) :6214-6221.