CH 5450
CH 5450 (Z-Ile-Glu-Pro-Phe-Ome) is a selective short peptide human cardiac chymase inhibitor. CH-5450 inhibits the action of rat MAB elastase 2 on substrate Ang I with an IC50 value of 49 µM and N-succinyl-Ala-Ala-Pro-Phe-p-nitroanilide with an IC50 value of 4.8 µM[1].
Product Specifications
CAS Number
252557-97-4
Product Name Alternative
Z-Ile-Glu-Pro-Phe-Ome
UNSPSC
12352209
Hazard Statement
H302, H315, H319, H335
Target
Proteasome
Type
Peptides
Related Pathways
Metabolic Enzyme/Protease
Applications
COVID-19-immunoregulation
Field of Research
Inflammation/Immunology
Assay Protocol
https://www.medchemexpress.com/Z-Ile-Glu-Pro-Phe-Ome.html
Purity
98.19
Solubility
DMSO : ≥ 43 mg/mL
Smiles
O=C(OC)[C@@H](NC([C@H]1N(C([C@@H](NC([C@@H](NC(OCC2=CC=CC=C2)=O)[C@@H](C)CC)=O)CCC(O)=O)=O)CCC1)=O)CC3=CC=CC=C3
Molecular Formula
C34H44N4O9
Molecular Weight
652.73
Precautions
H302, H315, H319, H335
References & Citations
Shipping Conditions
Blue Ice
Storage Conditions
-80°C, 2 years; -20°C, 1 year (Powder, sealed storage, away from moisture)
Scientific Category
Peptides
Clinical Information
No Development Reported
Available Sizes
Frequently Asked Questions
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